Generalised Thurston-Bennequin invariants for real algebraic surface singularities

A generalised Thurston-Bennequin invariant for a Q-singularity of a real algebraic variety is defined as a linking form on the homologies of the real link of the singularity. The main goal of this paper is to present a method to calculate the linking form in terms of the very good resolution graph of a real normal unibranch surface singularity. For such singularities, the value of the linking form is the Thurston-Bennequin number of the real link of the singularity. As a special case of unibranch surface singularities, the behaviour of the linking form is investigated on the Brieskorn double points x^m+y^n\pm z^2=0.Comment: 22 pages, TeX, 12 figure

The development of early expressive vocabulary in children with Down Syndrome

A delay in expressive language in children with Down Syndrome (DS) is common, and often a major challenge of the condition. This study aimed to investigate the early expressive vocabulary skills of Maltese children with DS, whose first languages were either Maltese or English, while taking into account chronological age. Language preference was further explored in the context of a bilingual environment. A multi-method design was implemented across seven participants whose language abilities ranged from the expression of single words in isolation to simple word combinations. The expressive vocabularies of four boys and three girls between 2;10 and 11;9 years were assessed through caregiver report, picture naming and language sampling. Performance of the children was analysed in relation to local findings on lexical production in typically-developing children. The study revealed that productive vocabularies of Maltese bilingual children with DS escalated with increasing age, notwithstanding inevitable individual variation.peer-reviewe

Androgens and Hypertension in Men and Women: a Unifying View.

This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure, but pathophysiological mechanism is not well understood. Androgens have an important effect on metabolism, adipose and endothelial cell function, and cardiovascular risk in both men and women. A focal point in this contest is represented by the possible gender-specific regulation of different tissues and in particular of the adipose cell. Available data confirm that androgen deficiency is linked to increased prevalence of hypertension and cardiovascular diseases. Adipocyte dysfunction seems to be the main involved mechanism. Androgen replacement reduces inflammation state in man, protecting by metabolic syndrome progression. In women, androgen excess has been considered as promoting factor of cardiovascular risk. However, recent data suggest that excessive androgen production has little effect per se in inducing hypertension in young women of reproductive age. Also in postmenopausal women, data on relative androgen excess and hypertension are missing, while adrenal androgen deficiency has been associated to increased mortality. RECENT FINDINGS: Molecular mechanisms linking androgen dysregulation to hypertension are almost Unknown, but they seem to be related to increased visceral fat, promoting a chronic inflammatory state through different mechanisms. One of these may involve the recruitment and over-activation of NF-kB, a ubiquitous transcription factor also expressed in adipose cells, where it may cause the production of cytokines and other immune factors. The NF-kB signalling pathway may also influence brown adipogenesis leading to the preferential enlargement of visceral adipocytes. Chronic inflammation and adipocyte dysfunction may alter endothelial function leading to hypertension. Both in men and in women, particularly in the post-menopausal period, hypoandrogenism seems to be a major determinant of the increased prevalence of hypertension. The relationship between androgen signalling and NF-kB might explain the pathophysiological mechanism leading to the development of endothelium dysfunction and hypertension

4 Vicars: Modern Dining on the Hill, Pre and After Dinner Drinks List

4 vicar\u27s hill Armagh BT617ED 028 3752 7772 [email protected]://arrow.tudublin.ie/menus21c/1126/thumbnail.jp

4 Vicars: Modern Dining on the Hill, Sample Drinks List

4 vicar\u27s hill Armagh BT617ED 028 3752 7772 [email protected]://arrow.tudublin.ie/menus21c/1124/thumbnail.jp

4 Vicars: Modern Dining on the Hill, Sample Lunch Menu

4 vicar\u27s hill Armagh BT617ED 028 3752 7772 [email protected]://arrow.tudublin.ie/menus21c/1125/thumbnail.jp

4 Vicars: Modern Dining on the Hill, Drinks Menu

4 vicar\u27s hill Armagh BT617ED 028 3752 7772 [email protected]://arrow.tudublin.ie/menus21c/1122/thumbnail.jp